Tumor-Associated Macrophages Facilitate the Proliferation and Migration of Cervical Cancer Cells

Tumor-associated macrophages (TAMs) are important components in tumor microenvironment. This study intended to explore the influence of TAMs on cervical cancer cells proliferation and migration. The expression levels markers, CD68 CD163, tissues were examined by immunohistochemistry increased with progression lesions (p < 0.05). M2-like phenotype (PMA(Polymethacrylate) induced THP-1 cells) noticed promote improve migration ability cells. These enhancements attributed secreting soluble physical contact between formation growth significantly faster mixed group SiHa than alone results indicated that interaction cells, including secretion contact, responsible for shaping immunosuppression microenvironments promoting cell